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Title   비소세포성 페암에서 혈청 및 조직의 c-erbB-2 종양 단백의 발현율과 상관 관계 ( C-erbB-2 Protein Expression and Correlation in Sera and Tumors of Non - Small Cell Lung Cancer Patients )
Publicationinfo   2000 Jan; 032(06): 1100-1109.
Key_word   Non-small cell lung cancer , C-erbB-2 , Gene
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Abstract   Purpose: We have examined the expression of c-erbB-2 oncogene in sera and tissues of non-small cell lung cancer patients. Materials and Methods: Serum levels of c-erbB-2 protein were measured by an enzyme immunoassay in 55 patients with non-small cell lung cancer. Sera from patients with surgical therapy were evalcated again after surgery. Immunohistochemical staining was performed in 47 of these tumors. Results: Elevated levels (45 U/mL, control mean +2SD) were observed in 15% of 55 non-small cell lung cancer patients, as compared with none of control subjects (p<0.05). The incidence of elevated level was higher in the adenocarcinoma than squamous cell carcinoma (22% vs 4%, p < 0.01). The serum levels of c-erbB-2 protein decreased significantly after surgical tumor ablation (p<0.01). Tissue overexpression was obtained in 23/47 cases (49%). The incidence of c-erbB-2 overexpression was higher in the adenocarcinoma (73% vs 29%, p<0.005). No relationship was found between c-erbB-2 protein expression in serum and tumor tissue and clinicopathologic feature. Elevated serum c-erbB-2 levels predicted tissue overexpression with sensitivity 30% and speciticity 96%. There was relationship between serum level and expression in tumor tissue of c-erbB-2 protein. Conclusion: Serum and tissue levels of c-erbB-2 correlate in patients with non-small cell carcinoma. Serum c-erbB-2 protein may be a useful indicator of tumor burden in patients with non-small cell lung cancer.
저 자   류헌모(Hun Mo Ryoo),이상엽(Sang Yeop Lee),이경희(Kyung Hee Lee),현명수(Myung Soo Hyun),김미진(Mi Jin Kim)